منابع مشابه
NoCut: Cytokinesis in Check
In this issue of Cell, Norden et al. (2006) describe a new pathway, NoCut, that links the completion of chromosome segregation to the onset of cytokinesis in budding yeast. In NoCut, Aurora kinase (Ipl1) at the spindle midzone negatively regulates cytokinesis through two proteins previously identified to be involved in cell polarity, Boi1 and Boi2.
متن کاملThe NoCut Pathway Links Completion of Cytokinesis to Spindle Midzone Function to Prevent Chromosome Breakage
During anaphase, spindle elongation pulls sister chromatids apart until each pair is fully separated. In turn, cytokinesis cleaves the cell between the separated chromosomes. What ensures that cytokinesis proceeds only after that all chromosome arms are pulled out of the cleavage plane was unknown. Here, we show that a signaling pathway, which we call NoCut, delays the completion of cytokinesis...
متن کاملMolecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check
In Escherichia coli, cytokinesis is orchestrated by FtsZ, which forms a Z-ring to drive septation. Spatial and temporal control of Z-ring formation is achieved by the Min and nucleoid occlusion (NO) systems. Unlike the well-studied Min system, less is known about the anti-DNA guillotining NO process. Here, we describe studies addressing the molecular mechanism of SlmA (synthetic lethal with a d...
متن کاملCytokinesis
Cytokinesis — the division of one cell into two daughters — is a complex event which, despite being studied for more than one hundred years, remains poorly understood. Although the end result of cytokinesis — two cells — is the same in all cell types, there are many different ways that cell division can occur. Most animal cells divide by forming a central constriction that pinches the cell into...
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ژورنال
عنوان ژورنال: Cell
سال: 2006
ISSN: 0092-8674
DOI: 10.1016/j.cell.2006.03.016